Longevity supplements – these active ingredients you should know
We all wish for a long life. This alone usually requires considerable effort. And we also want to be as healthy as possible in old age. This requires even more effort. In addition to sufficient exercise and a balanced diet, lifespan and quality of life in old age can also be influenced with nutritional supplements. Longevity nutritional supplements. This health guide explains what these supplements are, how they work, and what the current research suggests.
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The most important things in brief:
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Table of contents
- What is meant by longevity supplementation?
- Why Longevity Supplement?
- Typical active ingredients for Longevity dietary supplements
- Resveratrol
- Nicotinamide mononucleotide (NMN)
- Curcumin
- Spermidine
- Coenzyme Q10 (CoQ10)
- Ginkgo biloba
- Maca
- Longevity dietary supplement in the form of combination preparations
- Conclusion
What is meant by longevity supplementation?
| Longevity supplements include supplements designed to promote a long, healthy life with a high quality of life by providing nutrients important for maintaining mobility, cognitive abilities and preventing age-related diseases. |
To understand what Longevity supplements are all about, we first need to explain the two terms:
Longevity
Longevity is best translated into German as "longevity." It means a long life. Specifically, a long and healthy life with the greatest possible quality of life in old age. This means the best possible mobility, the best possible cognitive abilities, and as few age-related diseases as possible.
Dietary supplement
Dietary supplements include anything that serves to supplement your normal diet. These typically include nutrients such as vitamins, minerals, amino acids, fatty acids, fiber, and specific plant substances that you don't normally get or are unable to absorb in sufficient quantities through your diet.
The term longevity dietary supplement encompasses all supplements that are or could be beneficial to the above-mentioned goals.
Why Longevity Supplement?
| As we age, our well-being declines due to natural aging processes. Longevity supplements can help support health, cellular function, and the immune system. |
With increasing age, general well-being typically declines. This is due to the body's natural aging processes. While these cannot be prevented, they can be delayed or slowed down. There are several approaches to this: for example, exercise, sufficient rest, mindfulness, or a balanced diet.
However, you'll increasingly encounter difficulties when it comes to a balanced diet. Even if you consume only all foods considered healthy in the amounts appropriate for your individual needs, your body still won't get everything it needs to best combat the natural aging process. This is partly because our food is becoming increasingly nutrient-poor and, on top of that, sometimes contaminated with harmful substances. This is partly because you don't get some substances that studies have shown can have a positive effect on longevity, even with the most balanced diet. And that's precisely why longevity supplements exist.
High-quality Longevity supplements can help promote cellular health, reduce inflammation, strengthen the immune system, and improve overall health.
Typical active ingredients for Longevity dietary supplements
| Studies have shown that resveratrol, nicotinamide mononucleotide, curcumin, spermidine, coenzyme Q10, ginkgo biloba, and maca can have a positive effect on longevity. PUR4's dietary supplements contain these substances. |
Resveratrol
Resveratrol is a plant compound found in red grapes, berries, and some nuts. It is believed to have antioxidant properties and to be able to extend lifespan in model organisms.
- Resveratrol activates sirtuins, particularly sirtuin 1 (SIRT1), which are associated with longevity and metabolic regulation.
- One study showed that resveratrol extended lifespan and improved cardiovascular health in mice fed a calorie-restricted diet (Baur et al., Nature, 2006).
Source: Baur, JA, et al. (2006). "Resveratrol improves health and survival of mice on a high-calorie diet." Nature, 444(7117), 337–342.
Included in:
Nicotinamide mononucleotide (NMN)
NMN is a precursor to nicotinamide adenine dinucleotide (NAD+), a molecule essential for energy production in cells. NAD+ levels decline with age, which is associated with aging processes.
- NMN and other NAD+ precursors can help increase NAD+ levels, which can help the body repair age-related DNA damage.
- By supporting these DNA repair mechanisms, NMN can help maintain genome integrity and promote cellular health.
Source: Yao Z, Gao Z, Yang W, Jia P. Chronic nicotinamide mononucleotide supplementation enhances NAD+ metabolism and mitigates age-associated physiological decline in mice. Cell Rep. 2021 Dec 21;37(12):110143. doi:10.1016/j.celrep.2021.110143. PMID: 34936885.
Included in:
Curcumin
Curcumin, the active ingredient in turmeric, possesses powerful anti-inflammatory and antioxidant properties. It has the potential to prevent age-related diseases such as Alzheimer's, heart disease, and cancer.
- Curcumin influences various signaling pathways associated with inflammation, cell aging and oxidative stress.
- There are numerous animal and cell studies showing that curcumin has anti-inflammatory effects and can improve quality of life in old age. One clinical study showed that curcumin improved cognitive function in older adults with mild cognitive impairment.
Small, G.W., et al. (2018). "Curcumin and cognitive function in older adults: A randomized controlled trial." The American Journal of Geriatric Psychiatry, 26(3), 269-276.
Included in:
Spermidine
Spermidine is a polyamine found in many foods and plays a role in cell regeneration and growth. Spermidine is thought to promote autophagy, a process that degrades and recycles damaged cellular components.
- Spermidine appears to slow down cell aging by activating autophagy and thus maintaining cell health
- One study showed that spermidine extended lifespan and promoted cardiovascular health in mice.
Source: Eisenberg, T., et al. (2013). "Induction of autophagy by spermidine promotes longevity." Nature Cell Biology, 15(2), 297–305.
Included in:
Coenzyme Q10 (CoQ10)
CoQ10 is an antioxidant found in every cell of the body and plays a crucial role in energy production. CoQ10 levels decline with age, which has been linked to various age-related diseases.
- Supplementation with coenzyme Q10 has been shown to be a beneficial anti-aging agent, particularly under certain conditions associated with increased oxidative stress.
- CoQ10 has shown therapeutic benefits in age-related diseases, particularly cardiovascular and metabolic diseases.
Source: Diaz-Casado, E., et al. (2019) “The Paradox of Coenzyme Q10 in Aging” Nutrients 2019, 11(9), 2221.
Included in:
Ginkgo biloba
Ginkgo biloba is a tree species that has been growing on Earth for millions of years. An extract is extracted from the leaves of the ginkgo tree and used as a natural remedy.
- Ginkgo biloba can improve memory, cognition, memory scores, psychopathology, and quality of life.
- Ginkgo biloba can improve cerebral blood flow, executive function, attention/concentration, nonverbal memory, and mood.
- Ginkgo biloba can reduce stress, fasting serum glucose, glycated hemoglobin, insulin levels, body mass index, waist circumference, biomarkers of oxidative stress, the stability and progression of atherosclerotic plaques, and inflammation.
Source: Popa, D., et al. (2022). “Ginkgo biloba in the Aging Process: A Narrative Review”. Antioxidants 2022, 11(3).
Included in:
Maca
Maca (Lepidium meyenii) is a plant that grows in the high Andes of Peru, Bolivia, and Ecuador. The plant has been used as a food and medicinal plant for centuries.
- Maca has systemic biological effects, including anti-inflammatory and antioxidant effects. These may improve cognitive function in old age. Macamides are crucial in this regard. These inhibit the enzyme FAAH, which plays an important role in regulating CB1 and CB2 receptors.
- Maca has the ability to reduce IL-6—a major inflammatory cytokine—suggesting anti-inflammatory properties that may improve quality of life in old age.
- Maca exhibits significant antioxidant properties and reduces oxidative stress associated with cell damage. In cell cultures, it exhibits antiperoxidative effects and fights cancer cells.
- Maca is increasingly being used for diabetes management because of its ability to lower blood sugar and lipid oxidation, preventing oxidative liver damage. It also increases insulin levels, which contributes to better blood sugar regulation.
Sources:
- Peres ND, Bortoluzzi LC, Marques LL, Formigoni M, Fuchs RH, Droval AA, Cardoso FA. Medicinal effects of Peruvian maca (Lepidium meyenii): A review. Food & function. 2020;11(1):83-92.
- Wang Y, Wang Y, McNeil B, Harvey LM. Maca: An Andean crop with multi-pharmacological functions. Food Research International. 2007 Aug 1;40(7):783-92.
- Lee E, Park M, Kim B, Kang S. Effect of Black Maca Supplementation on Inflammatory Markers and Physical Fitness in Male Elite Athletes. Nutrients. 2023 Mar 27;15(7):1618.
Longevity dietary supplement in the form of combination preparations
| Combination products for longevity supplements are convenient because they combine all the necessary active ingredients in a single container, eliminating space constraints, time-consuming tasks, and numerous individual orders. Important selection criteria include active ingredient composition, dosage, raw material quality, and clinical trials. |
Why Longevity dietary supplements as combination products?
If you regularly consume dietary supplements, you can probably imagine why combination supplements are a convenient option. They give you everything you need from a single supplement, avoiding the typical inconveniences of supplementation.
For example, the typical space problem that arises when you have to take all of the active ingredients mentioned above as individual capsules. With the Longevity supplement, that would mean seven individual, often unsightly containers that you'd have to store somewhere. If you opt for a combination product, it's just one container. And if you choose one of our combination products, you don't even have to hide the container – PUR4 containers also look good.
Another typical problem for supplement users: the time it takes. Opening seven containers, removing the correct number of capsules, screwing the container back on, and storing it away, especially in the evening after a long and stressful day, is frustrating. With a combination supplement, you save yourself the daily pill odyssey. Open it once, remove the capsules once, screw the lid back on. Done.
Probably the most annoying problem with single medications: The containers are never empty at the same time, but always at different times. This means you have to place numerous individual orders and, quite often, a temporary shortage. You can also elegantly circumvent this with combination medications.
And why do we think combination supplements make sense? Because many of the active ingredients used in PUR4 dietary supplements reinforce each other. This results in a significantly greater effect than with individual supplements.
What is important about longevity combination products?
What defines a high-quality longevity combination supplement? Among other things, the composition of the active ingredients. Are these substances proven to have an impact on your longevity? How many active ingredients are included? Do the active ingredients produce synergistic effects? You should ask yourself, the manufacturer, or your doctor these questions before deciding on a specific longevity dietary supplement as a combination supplement.
The dosage of the individual active ingredients also plays a crucial role in assessing the quality of longevity dietary supplements in the form of combination preparations. Only at the appropriate dosage do the active ingredients have any chance of providing the desired effect.
Last but not least, the quality of the raw materials is also important. How potent are they? Are the raw materials pure, or contaminated with pesticides and fungicides? And from a moral perspective: Do the producers of the raw materials receive a fair wage for their work?
And: Has the Longevity combination product been clinically tested? And if so, where?
These points are important if you want to assess the quality of a Longevity combination product. It's best to first search for information on the manufacturer's website or contact customer support.
Conclusion
Longevity supplements are a broad field, and one that more and more sales-savvy manufacturers are jumping on. With this guide, you now have a kind of handbook at your side, designed to help you separate the wheat from the chaff. You now know what longevity supplements are all about and which active ingredients have been proven to have an effect on your longevity. At the same time, however, you are also aware (at least now) that longevity supplements can only produce the desired effects in combination with a corresponding lifestyle. And you know what combination supplements are and why, in our opinion, they are the far better solution.
And if you want to know anything else, just write us your question.